Immunohematology Syllabus for 2021-2022
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West Campus, Allied Health, Office 125

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Course Information

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MLAB-2431-001 Immunohematology


Course Description

A study of blood antigens and antibodies. Presents quality control, basic laboratory technique and safety. Includes the principles, procedures and clinical significance of test results in genetics, blood group systems, pre-transfusion testing, adverse effects of transfusions, donor selection and components, and hemolytic disease of the newborn.

Student ResourcesStudent Resources Website

Department Expectations

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Notice to Students enrolled in an educational program for preparation of issuance of certain occupational licenses:

Students enrolled in an educational program in preparation for obtaining certain occupational licenses are potentially ineligible for such license if the student has been convicted of an offense. For further information, please contact:

Melodie Graves
Justice Involved Advocate
Student Service Center 117
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(4 sem hrs; 2 lec, 5 lab)

Class Type

On Campus Course

Syllabus Information


Basic & Applied Concepts of Blood Banking and Transfusion Practices, 5th Edition, Howard, Elsevier 2020. 

IBSN 978-0323697392


The supplies include the following:

  • Textbook(s) and lab manual
  • Computer or Tablet with Respondus Lockdown browser installed
  • Internet access
  • Disposable lab coat
  • Gloves (preferably nitrile) not vinyl
  • Sharpies
  • Pens/pencils/paper

Student Performance

Students are expected to complete all reading assignments, written assignments, quizzes and exams.  All assignments, as well as their due dates are noted on the course calendar.  It is the student’s responsibility to check the course calendar regularly, and complete al assignments by their due date.  If a student knows that he or she is going to be absent when an assignment is due, he/she needs to contact the course instructor to turn in the assignment early.  Laboratory assignments cannot be made up.  If a student misses a lab session, he/she needs to review that lab sessions and complete any questions that accompany the assignment.

Course Learning Objectives

Cognitive Objectives

After attending lecture, reading the assigned materials, and completing all assignments and activities for this course, the student will be able to do the following:

1. Apply principles of safety, quality assurance and quality control in Immunohematology.

2. Describe and apply the regulations of the agencies that govern activities in the blood bank, including the Food and Drug Administration and AABB.

3. Describe blood group genetics, characteristics of the blood group systems, and the principles of immunology as they relate to Immunohematology.

4. Compare and contrast the genetic theories behind the Fisher-Race and Wiener terminologies and translate from one to the other.

5. Describe reagents used in the Immunohematology lab including antisera, reagent red blood cells, lectins, potentiators, and antihuman globulin.

6. Describe the basic principles of routine testing in immunohematology and correlate test results with patient conditions.

7. Apply critical thinking skills to solve issues associated with reagent performance and red cell suspensions.

8. Describe the principles of gel technology, microplate techniques, and solid-phase RBC adherence techniques.

9. Describe and resolve ABO discrepancies caused by extra or missing reactions in serum testing.

10. Describe blood group system antibodies with regard to immunoglobulin class, clinical significance, and in vitro serologic reactions.

11. Solve complex antibody problems and select donor units compatible for transfusion to patients with antibodies.

12. Describe the preparation, storage, and use of blood components and determine if they meet acceptable AABB standards and Food and Drug Administration (FDA) guidelines.

13. Discuss the cause of hemolytic disease of the fetus and newborn (HDFN), correlate tests included the prenatal workup, and treatment options available.

14. Discuss the composition, eligibility criteria, and principle of Rh immune globulin (RhIG).

15. Discuss the pathophysiology and transfusion needs of patients with various disease states.

16. Compare and contrast the distinguishing features of transfusion reactions and preventative measures that can be taken.

17. List donor requirements and required laboratory tests on donor blood.

18. Evaluate acceptable donors based on their medical history and physical examination.

19. Collaborate and analyze case studies in Immunohematology with classmates.

Psychomotor Objectives:

After attending lecture and laboratory sessions and reading the assigned materials, the student will be able to:

20. Accurately grade and interpret observed test reactions.

21. Demonstrate knowledge of the vocabulary utilized in this course by completing all study questions and other assigned learning activities.

22. Resolve case studies in Immunohematology based on information provided.

23. Collaborate on classroom discussions and question/answer sessions.

24. Perform laboratory exercises as directed and answer all questions associated with each individual laboratory assignment.

Affective Objectives:

During this section, the students will exhibit the following professional behaviors, as evaluated in the Work Ethics component of this course:

25. The student will attend all lecture and laboratory sessions.

26. The student will perform all reading assignments, take his/her exams/quizzes, and complete all assigned activities independently, unless asked to work with a partner.

27. The student will demonstrate the honesty and integrity to perform these tasks, as expected, with emphasis on quality and timeliness.

28. The student will participate in discussions regarding honesty, integrity and responsibility, as they relate to legal and ethical issues in the clinical laboratory.

29. The student will demonstrate respect for his/her classmates, instructor, and all other students regardless of their race, color, national origin, sex, age, religion or disability.

Students Rights and Responsibilities

Student Rights and Responsibilities

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Expected Student Behavior


Academic dishonesty shall constitute a violation of the college rules and regulations and is punishable as prescribed by Amarillo College Board policies. Academic dishonesty shall include, but is not limited to, cheating on a test/quiz/assignment, plagiarism, and collusion. Cheating shall include:

• Copying from another student's test/assignment paper.

• Using test materials not authorized by the person administering the test/assignment (ex: notes, books, etc).

• Collaborating with or seeking aid from another student during a test/assignment without permission from the test/assignment administrator/instructor.

• Knowingly using, buying, selling, stealing, or soliciting, in whole or in part, the contents of an administered/unadministered test/assignment.

• The unauthorized transporting or removal, in whole or in part, of the contents of the administered/unadministered test/assignment.

• Substituting for another student, or permitting another student to substitute for one's self, to take a test/assignment.

• Bribing another person to obtain an administered/unadministered test/assignment or information about an administered/unadministered test/assignment.

Plagiarism shall be defined as the appropriating, buying, receiving as a gift, or obtaining by any means another's work and the unacknowledged submission or incorporation of it in one's own written work.

Collusion shall be defined as the unauthorized collaboration with another person in preparing written work for fulfillment of course requirements.

Students may not use books, computer websites, or collaborate with another individual when completing quizzes, exams, or assignments in this course unless specifically directed to do so by their instructor.


Amarillo College and the Medical Laboratory Technology program are committed to developing knowledge, skills, attitudes, and behaviors in students so that they can obtain entry-level employment and advance in their chosen profession. Great measures are taken to ensure that the curriculum is updated and that equipment is purchased and kept at industry level, as much as possible. Program Advisory committees meet annually to ensure that the curriculum meets the needs of the local medical community as well as the program's national accrediting agency.

We are committed to providing these things to ensure that a graduate has the skills and knowledge to obtain and advance in their chosen profession. Therefore, professional education must address more than academic and skills training in order to meet this challenge. Business and industry state that their greatest need is for employees who possess strong work ethics. Therefore, we accept the challenge of providing not only academic and hands-on training but also work ethics training to students. The work ethics program is important because it provides the link between academic knowledge, skills training and successful employment in the workforce. The program focuses on those behaviors expected in a professional environment.

The following work ethics have been identified as being most important to professional employers, and will be covered and evaluated on a weekly basis, each semester, throughout the program:

• Attendance

• Character

• Teamwork

• Appearance

• Attitude

• Productivity

• Organization

• Communication

• Cooperation

• Respect

NOTE: If a student is absent during a scheduled lecture/lab period, he/she cannot be awarded points for work ethics during that missed lecture/lab period.

Phones and Smartwatches

Phones and smartwatches are disruptive during lecture and lab sessions. Phones and smartwatches should be turned-off during class time, or set on vibrate during class time. If the student anticipates an emergency during class time, they should leave the number for the Student Services Office with their contact. The number is 371-5300

Text/Instant Messaging is NOT permitted when lectures and labs are in session.  It is disruptive and disrespectful to fellow students and the course instructor. Students who are caught engaging in either of these will be subject to disciplinary action including, but not limited to:

1. Being asked to leave class for the remainder of the day

2. Mandatory conference with the Dean of Health Sciences

3. Conference with the Vice President of Student Affairs and a permanent entry in the student's official

program record

The ONLY exception that will be made is if the student has discussed the situation with their instructor beforehand, and ONLY for emergency purposes.

Grading Criteria

The course components of this course will be weighted as follows:

Lecture = 60% of the total grade

  •  Exams – 100 points, each
  • Quizzes - 5-25 points possible, each. Quizzes for each chapter will be given at the beginning of class on the day the chapter is covered.
  •  Notebook – 25 points
  • Assignments

Lab = 10% of the total grade

  • Lab Experiments/Study Questions - 10-25 points each
  • Please note that if the lab has study questions associated with it, they will be due at the beginning of class/lab. Study questions are to prepare the student for the laboratory exercise. The student will not be permitted to participate in lab if they have not completed the study questions.                        
  • Lab Practical – 200 points

Work Ethics = 10% of the total grade

  • 0-10 points possible per class day, as evaluated by their instructor.

  • Points awarded will be based on ALL areas defined in the Work Ethics component of this course including: Attendance, Character, Teamwork, Appearance, Attitude, Productivity, Organization, Communication, Cooperation, and Respect. Failure to demonstrate positive work ethics in any of these components will result in points being deducted from the student’s work ethics grade. If the student is disruptive to the class or lab, they will be asked to leave for the remainder of the day, and will not be awarded points for work ethics.

Final Exams = 20% of the total grade

The grading scale used for this course is as follows:

A = 90.0% - 100.0% of the total points possible for the course

B = 80.0% - 89.9% of the total points possible for the course

C = 70.0% - 79.9% of the total points possible for the course

F = 69.9% or less of the total points possible for the course

NOTE: A grade of 'D' is not possible

Examinations and quizzes may not be made up. Students are not allowed to make up the labs. The study questions for each lab are due the day the lab is performed.

Major examinations will be given over the lecture and reading material. A comprehensive final will be given at the end of this course in class. Quizzes may be given, announced or unannounced, at any time, so the student is advised to complete all assignments in a timely manner in order to be successful on quizzes.

Late Assignment Policy

Students are required to observe and abide by all assignment due dates. Assignments turned in after the specified date will only be accepted at the discretion of the instructor. Assignments that are time-sensitive, or are required prior to completing other tasks (ex. Pre-lab assignments), may not be accepted.

Zero credit or reduced credit (maximum grade given will be equivalent to a reduction in 2 letter grades) will be given for assignments turned in after the specified date. This is at the discretion of the instructor. It is essential that students be aware of all assignment due dates.

Mandatory Tutoring

If a student makes a grade below a 75% on any given quiz or exam they will be required to attend and show proof of a minimum of 1 hour of tutoring as directed by the instructor. Tutoring will need to be completed prior to the next exam. If there are scheduling conflicts, the instructor must be notified immediately in order to provide alternative skill-building assignments.


Incompletes are granted only for emergency situations such as hospitalization of the student just prior to the final exam, serious injury to the student on the day of the final exam, etc. Incompletes will not be granted for situations involving vacation plans, transportation difficulties, appointments, etc. Students who need to request an incomplete must do so prior to the scheduled time of the final exam with appropriate documentation given to the instructor.


No administrative drops/withdrawals will be initiated by program officials.  It is the responsibility of each student to drop or withdraw from a course. Students can drop a course via ACconnect, and must do so prior to the last day to drop/withdraw as posted on the Amarillo College Master Calendar. Students should be aware that failure to attend class does NOT result in being automatically dropped from a course, and WILL result in a grade of “F”.

Students should be advised that they may repeat a MLAB course only one time, and may repeat no more than two courses while enrolled in the program. The term “repeat” shall be interpreted to mean re-enrollment following withdrawal, drop or an unsatisfactory grade from a class. Students who are forced to completely withdraw from the college during a given semester may re-apply for admission to the program. Once the student has actually begun the program, he/she must complete all MLAB major courses within 36 months.


If a student is having a problem with the course policies or the instructor, he or she should first try and resolve any such problems through the instructor. If the problem is not resolved, the student may proceed to the Program Director, the Associate Dean of Health Sciences (Kim Boyd) the Dean of Health Sciences (Kim Crowley), Associate Vice President of Academic Affairs (Becky Burton), Vice President of Academic Affairs (Dr Tamara Clunis), and the College President (Dr Russel Lowery-Hart), IN THAT ORDER.


Regular attendance is necessary for satisfactory achievement. Therefore, it is the responsibility of the student to attend class. Attendance is included in the Work Ethic grade throughout the course which is a component of the overall grade for this course. Attendance includes arriving for class late and leaving early.  Less than 90% attendance in a course may result in failure of the course.  Students are required to notify faculty in advance of class absence.






Week 1

Blood Bank Syllabus and Schedule

Ch 1: Quality Assurance and Regulation of the Blood Industry and Safety Issues in the Blood Bank

Ch 1 HW due

Lab 1: Cell Suspension

Exam 1

Week 2

Ch 2: Immunology: Basic Principles and Applications in the Blood Bank

Ch 2 HW due

Lab 2: Grading Reaction Strength

Lab 3: ABO Rh Testing

Ch 3: Blood Banking Reagents: Overview and Applications

Ch 3 HW due

Lab 3 cont.

Spring Break

Week 3

Ch 4: Genetic Principles in Blood Banking

Ch 4 HW due

Lab 4: IAT washing

Lab 5: IAT

Exam 2

Chp 2-4

Lab 5 cont.

Week 4

Ch 5: ABO and H Blood Group Systems and Secretor Status

Ch 5 HW due

Lab 6: Potentiators

Ch 6: Rh Blood Group System

Ch 6 HW due

Lab 7: Antibody ID

Week 5

Ch 7: Other Red Cell Blood Group Systems, Human Leukocyte Antigens, and Platelet Antigens

Ch 7 HW due

Lab 7: Antibody ID cont.

Exam 3

Chp 5-7

Lab 7 cont.

Week 6

Ch 8: Antibody Detection and Identification

Ch 8 Worksheets (In-class)

Ch 8 HW due

Lab 8: Compatibility

Ch 9: Compatibility Testing

Ch 10: Blood Bank Automation for Transfusion Services

Ch 9 & 10 HW due

Lab 9: DAT

Week 7

Exam 4

Chp 8-10

Lab 10: Prenatal Workup

Ch 11: Adverse Complications of Transfusions

Ch 12: Hemolytic Disease of the Fetus and Newborn

Ch 11 & 12 HW due

Lab 11 Antibody Titration

Lab 12 Rh-immune workup

Week 8

Exam 5

Chp 11-12

Mock practical

Ch 13: Donor Selection and Phlebotomy

Ch 14: Testing of Donor Blood

Ch 13 & 14 HW due

Mock practical

Week 9

Exam 6

Chp 13-14


Ch 15: Blood Component Preparation and Therapy

Ch 16: Transfusion Therapy in Selected Patients


Ch 15 & 16 HW due


Week 10

Blood Bank Final

On Campus - Tuesday May 10th

This is a tentative course calendar. The instructor will always notify students if there is going to be a change in the calendar. It is the student's responsibility to check course announcements, course email, and/or GroupMe messages on a regular basis in order to be notified of any changes in the calendar.

Additional Information

Syllabus Created on:

12/22/21 10:16 AM

Last Edited on:

02/14/22 10:20 AM